A case study in accelerating solid oral dosage form development through simultaneous multi-objective optimization.
background
Solid oral dosage form
Only enough material for
~ 20 formulations
Solution required in
< 4 weeks
OUR SOLUTION
Multi-objective optimization
Design
Execute
Learn
Optimize
Optimize tablet hardness
Maximize drug release kinetics
Maximize content uniformity of powder blends
Minimize the angle of repose in powder blends
VALIANTᵀᴹ identifies diverse solutions to the multi-objective problem through nine batches of experimentation.
Results
Critical objectives optimized simultaneously
*Disclaimer
The plotted values are not raw experimental values. The data have been transformed to protect confidential information while preserving the overall trends and relationships needed to communicate the case study.
insights
Key takeaways
Platform uptime: nine days
Sample efficiency
AI precisely identifies lead candidates with maximum sample efficiency (< 1% of possible experiments conducted).
Ready to scale
Unmatched agility
Multi-objectives are simultaneously optimized in nine learning cycles, including two requested objective changes.
